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Drug trial casts doubt over cannabis-based painkiller for MS sufferersLast updated at 21:47pm on 8th April 2008
![]() A painkiller containing THC, the active ingredient in cannabis, is used by 1,400 MS sufferers
Sativex, which contains THC, the active ingredient in cannabis, is being used as a painkiller by around 1,400 MS sufferers in Britain. The mouth spray's makers, Wiltshire-based GW Pharmaceuticals, also hope to market it to ease the muscle spasms associated with MS and the pain of cancer. However, its worth has been thrown into doubt by a test involving more than 300 MS patients. While half of those taking Sativex found their pain was reduced by at least 30 per cent, those using a dummy spray fared almost as well. GW said the result could be explained by an "unexpectedly strong placebo response" - in which symptoms are eased by the simple belief that a treatment will work. The news sent the company's shares plummeting by as much as 31 per cent. GW, however, remains adamant there was a place for Sativex on the pharmacist's shelf. Managing director Justin Gover said there was a ' desperate need' for new pain treatments and the drug had a "real role" to play. The treatment, which is sprayed under the tongue four or five times a day, first went on the market in Canada in 2005. Britain's drug regulators have yet to deem it safe and effective. However, doctors can prescribe it on a 'named patient' basis, which means they take personal responsibility for giving the drug. A typical daily treatment of five sprays costs around £4. GW grows 40,000 cannabis plants a year at a secret location in the English countryside.
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